Ayew picked some knocks in the Black Stars disappointing 0-0 draw game with Uganda on Friday and is expected visit the injury room for some weeks treatment.
He played full throttle in the game but failed to find target for Avram Grant’s side.
The striker is presently at the Bodymoor Heath center in Birmingham receiving treatment.
He is unlikely to recover in time for the Saturday’s derby at the Villa Park.
Ayew has featured in all of Aston Villa’s 12 this season.
A lot would be expected from Ayew after revitalization under new Manager Steve Clarke.