The South Korean has scored 18 goals in 39 games so far this season and is one of the most in form players of his club.
Ghana play against the Asians on November 28th at the Education City stadium in Al Rayyan during the second round of group stage games.
Son has 125 goals for Tottenham Hotspurs since joining from Bayern Leverksusen in 2015.
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The Premier League star is one of the most consistent players in England and will be a headache for the Black Stars defenders.