Brighton and Hove Albion defender Tariq Lamptey was handed his Black Stars debut as they lost 3-0 to Brazil.
Lamptey was brought on in the second half to replace Baba Iddrisu and his performance was an encouraging one, maintaining solidity at the back.
Ghana went down inside eight minutes after Marquinhos headed in a corner kick.
In the 27th minute, Richarlison finished off a slick team move to make it 2-0.
Richarlison once again found the net just before half time to put the game to bed for the Seleccao.
Ghana will now turn their attention to Nicaragua in Spain on Tuesday.