Black Satellites suffered defeat after beginning their 2022 Toulon tournament with a narrow defeat to North America giant Mexico.
The Ghana U20 team succumbed to a 1-0 defeat after falling to an 83rd-minute strike by their opponents.
Mexican midfielder Victor Guzmán scored the only goal of the encounter with a low shot into the corner, leaving the goalkeeper with no chance to save the goal bound strike.
Ghana created few openings in the game but failed to take them as they were unable to hit the back of the net.
The Black Meteors are in Group B, alongside Mexico, Venezuela, and Indonesia. The other group game ended in a 1-0 victory for Venezuela.
Ghana’s next game is against Indonesia on Thursday before facing Venezuela on Sunday in their last group game.