The hard-working enforcer picked what appeared to be a knee injury during Leicester City’s 2-1 defeat at Stade Rennes in the second leg of their UEFA Conference League on Thursday.
Leicester City manager Brendan Rodgers confirmed the unpleasant news.
Though the extent of the injury is, meanwhile, yet to be known.
However, it seems the midfielder suffered the hitch around the medial ligament in his knee.
“Marc Albrighton has a groin injury and Wilfred Ndidi is block tackle so he injured the medial ligament in his knee so will see how that is,” Leicester City manager Brendan Rodgers told BT Sports.
Nigeria coach Austin Eguavoen could be handed a devastating fear should he miss the services of the 25-year old going into the double-header games against the Black Stars for a World Cup spot.
Ndidi has been ever-present for the three-time Africa champions since making debut against DR Congo in 2015.
Ghana will host Nigeria in the first leg of the 2022 World Cup Playoffs on 25th March 2022 before they make a trip to Abuja four days later for the reverse fixture.
FULL SQUAD:
Goalkeepers: Francis Uzoho (AC Omonia, Cyprus); Daniel Akpeyi (Kaizer Chiefs, South Africa); Maduka Okoye (Sparta Rotterdam, The Netherlands)
Defenders: Oluwasemilogo Ajayi (West Bromwich Albion, England); Kenneth Omeruo (CD Leganes, Spain); Leon Balogun (Glasgow Rangers, Scotland); William Ekong (Watford FC, England); Olaoluwa Aina (Torino FC, Italy); Calvin Bassey (Glasgow Rangers, Scotland); Abdullahi Shehu (AC Omonia, Cyprus); Zaidu Sanusi (FC Porto, Portugal)
Midfielders: Frank Onyeka (Brentford FC, England); Joseph Ayodele-Aribo (Glasgow Rangers, Scotland); Wilfred Ndidi (Leicester City, England); Oghenekaro Etebo (Watford FC, England); Akinkunmi Amoo (FC Copenhagen, Denmark)
Forwards: Ahmed Musa (Fatih Karagumruk, Turkey); Samuel Chukwueze (Villarreal FC, Spain); Victor Osimhen (Napoli FC, Italy); Moses Simon (FC Nantes, France); Sadiq Umar (UD Almeria, Spain); Odion Jude Ighalo (Al-Hilal FC, Saudi Arabia); Kelechi Iheanacho (Leicester City, England); Emmanuel Dennis (Watford FC, England); Ademola Lookman (Leicester City, England)
Standby: Chidozie Awaziem (Alanyaspor FC, Turkey); Jamilu Collins (SC Padeborn 07, Germany); Chidera Ejuke (CSKA Moscow, Russia); Taiwo Awoniyi (Union Berlin, Germany); Paul Onuachu (KRC Genk, Belgium); Peter Olayinka (SK Slavia Praha, Czech Republic); Ogenyi Onazi (Al-Adalah FC, Saudi Arabia)